Our Research

Lei S, Gangrade H, Bajpayi S, Gong Q, Hall C, Yoo EJ, Sidoli S, Senoo N, Boulias K, Claypool SM, Timp W, Tampakakis E. Stoichiometric m6A regulation of YY1 orchestrates the metabolic switch during cardiac development. bioRxiv. 2026;2026.09.25.754444.

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Li B, Liu X, Murphy S, Tampakakis E, Kwon C. Decoding cardiac development and maturation at single-cell and spatial transcriptomic resolution. Circ Res. 2026 Jul 31;139(4).

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Senoo N, Sheridan MS, Wohlfarter Y, Primrose MT, Tampakakis E*, Keller MA, Claypool SM. Disturbed mitochondrial maturation in cardiolipin remodeling-deficient cardiomyocytes. iScience. 2026 Mar 20;29(3). *Corresponding author

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Htet M, Lei S, Bajpayi S, Gangrade H, Arvanitis M, Zoitou A, Murphy S, Chen EZ, Koleni N, Lin B, Kwon C, Tampakakis E*. A transcriptional enhancer regulates cardiomyocyte maturation. Nature Cardiovascular Research. *Corresponding author

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Habecker BA, Bers DM, Birren SJ, Chang R, Herring N, Kay MW, Li D, Mendelowitz D, Mongillo M, Montgomery JM, Ripplinger CM, Tampakakis E, Winbo A, Zaglia T, Zeltner N, Paterson DJ. Molecular and cellular neurocardiology in heart disease. Journal of Physiology. 2024 May 22. doi: 10.1113/JP284739

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Li W, Lipsius K, Burns NG, Sato R, Rehman A, Xue H, Combs C, Minichiello L, Gangrade H, Tampakakis E, Mukouyama YS. Vascular smooth muscle cell-derived nerve growth factor regulates sympathetic collateral branching to innervate blood vessels in embryonic skin. Biology Open. 2024 May 15;13(5):bio060147.doi: 10.1242/bio.060147

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Kumari R, Pascalau R, Wang H, Bajpayi S, Yurgel M, Quansah K, Hattar S, Tampakakis E, Kuruvilla R. Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.  Cell Reports, 2024 Feb 27;43(2):113674. doi: 10.1016/j.celrep.2024.113674. 

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Htet M, Lei S, Bajpayi S, Zoitou A, Chamakioti M, Tampakakis E. The role of noncoding genetic variants in cardiomyopathy. Front Cardiovasc Med. 2023 May 22;10:1116925. doi: 10.3389/fcvm.2023.1116925.

 

Miyamoto M, Kannan S, Anderson MJ, Liu X, Suh D, Htet M, Li B, Kakani T, Murphy S, Tampakakis E, Lewandoski M, Andersen P, Uosaki H, Kwon C.  Cardiac progenitors instruct second heart field fate through Wnts. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2217687120. doi: 10.1073/pnas.2217687120.

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Mapps AA, Boehm E, Beier C, Keenan WT, Langel J, Liu M, Thomsen MB, Hattar S, Zhao H, Tampakakis E, Kuruvilla R. Satellite glial cells modulate sympathetic neuron survival, activity and autonomic function. Elife. 2022 Aug 23;11:e74295. doi: 10.7554/eLife.7429. 

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Kowalski W, Garcia-Pak IH, Li W, Uosaki H, Tampakakis E, Zou J, Lin Y, Patterson K, Kwon C, Mukouyama Y. Sympathetic neurons regulate cardiomyocyte maturation in culture. Front Cell Dev Biol 2022 Mar 11;10:850645. doi: 10.3389/fcell.2022.850645.  

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Tampakakis E*, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama Y, Lee G, Minichiello L, Kwon C. Heart neurons use clock genes to control myocyte proliferation. Sci Adv. 2021 Dec 3;7(49):eabh4181. doi: 10.1126/sciadv.abh4181. Epub 2021 Dec 1. * Co-corresponding author

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Miyamoto M, Andersen P, Sulistio E, Liu X, Murphy S, Kannan S, Nam L, Miyamoto W, Tampakakis E, Hibino N, Uosaki H, Kwon C. Noncanonical Notch signals have opposing roles during cardiac development. Biochem Biophys Res Commun, 2021 Sep 2;577:12-16

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Tampakakis E, Mahmoud A. The Role of Neurons and Hormones on Cardiomyocyte Maturation. Semin Cell Dev Biol. 2021 Oct;118:136-143.

 

Miyamotto M, Gangrade H, Tampakakis E,* Understanding heart field progenitor cells for modelling congenital heart diseases. Current Cardiology Reports. 2021 Mar 11;23(5):38 *Corresponding author

 

Murphy S, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen D, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C. PGC1/PPAR Drive Cardiomyocyte Maturation at a single cell level via Yap1 and SF3B2. Nature Communications 2021 Mar 12;12(1):1648.

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Arvanitis M, Tampakakis E, Zhang Y, Wang W, Auton A, 23andMe Research Team, Dutta D, Glavaris S, Keramati A, Chatterjee N, Chi NC, Ren B, Post WS, Battle A. Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to Heart Failure. Nature Communications, 2020  Feb 28;11(1):1122

 

Tampakakis E*, Andersen P*, Jimenez D, Kanan S, Chelko S, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Kwon C. Precardiac organoids form two heart fields via Bmp/Wnt signaling.  Nature Communications, 2018 Aug 7;9(1):3140 *Equal contribution

 

Tampakakis E, Shah SJ, Borlaug BA, Leary PJ, Patel HH, Miller WL, Kelemen BW, Houston BA, Kolb TM, Damico R, Mathai SC, Kasper EK, Hassoun PM, Kass DA, Tedford RJ. Pulmonary effective arterial elastance as a measure of right ventricular afterload and its prognostic value in pulmonary hypertension due to left heart disease. Circ Heart Fail. 2018 Apr;11(4):e004436.

 

Cho GS*, Tampakakis E*, Andersen P, Kwon C. Use of a neonatal rat system as a bioincubator to generate adult-like mature cardiomyocytes from human and mouse pluripotent stem cells. Nature Protocols. 2017 Oct;12(10):2097-2109. *Equal contribution

 

Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA, Kwon C. Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Reports 2017 Jan 10;18(2):571-582.

 

Oh Y, Cho G, Li Z, Kim MJ, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional coupling with cardiac muscle promotes maturation of hPSC-derived sympathetic neurons. Cell Stem Cell. 2016 Jun 15. pii: S1934-5909(16)30086-8.

 

Tampakakis E. Tabit CE, Holbrook M, Linder EA, Berk BD, Frame AA, Fetterman JL, Gocke N, Vita JA, Hamburg NM. Intravenous lipid infusion induces endoplasmic reticulum stress in endothelial cells and mononuclear cells of healthy adults. J Am Heart Assoc. 2016 Jan 11;5(1). pii: e002574

 

Tampakakis E, Leary PJ, Selby VN, De Marco T, Cappola TP, Felker GM, Russell SD, Kasper EK, Tedford RJ. The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease. JACC Heart Fail. 2015 Jan;3(1):9-16.

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Tampakakis E, Peleg AY, Mylonakis E. Interaction of Candida albicans with an intestinal pathogen; Salmonella enterica serovar Typhimurium. Eukaryot Cell. 2009 May;8(5):732-7.

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Means TK, Mylonakis E, Tampakakis E, Puckett L, Stewart CR, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury JB. Evolutionary-conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009 Mar 16;206(3):637-53.

 

Tampakakis E, Okoli I, Mylonakis E. A C. elegans-based, whole animal, in vivo screen for the identification of antifungal compounds. Nat Protoc. 2008 Nov;3(12):1925-1931.

 

Peleg AY, Tampakakis E, Fuchs BB, Eliopoulos GM, Moellering RC Jr, Mylonakis E. Prokaryote-eukaryote interactions identified using Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14585-14590.